Use with caution.
Potential for decreased elbasvir/grazoprevir concentrations; clinical significance unknown. May be more relevant with high amounts of chronic garlic intake.
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The information in this website/app is intended for use by and with experienced physicians and pharmacists. The information is not intended to replace sound professional judgment in individual situations, and should be used in conjunction with other reliable sources of information. Due to the rapidly changing nature of information about HIV treatment and therapies, users are advised to recheck the information contained herein with the original source before applying it to patient care. Decisions about particular medical treatments should always be made in consultation with a qualified medical practitioner knowledgeable about HIV-related illness and the treatments in question.
Neither Toronto General Hospital, Alberta Health Services, the Ottawa Hospital, nor the authors and contributors are responsible for deletions or inaccuracies in information or for claims of injury resulting from any such deletions or inaccuracies. Mention of specific drugs, drug doses or drug combinations within this website does not constitute endorsement by the authors, Toronto General Hospital, Alberta Health Services or the Ottawa Hospital.
We emphasize that program only checks for interactions between HIV or HCV drugs and other drugs, it will NOT check for interactions between sets of non-HIV or HCV drugs.
Also, program content focuses primarily on pharmacokinetic based interactions, and will not include comprehensive data on pharmacodynamics interactions, including QT prolongation.
Last updated: January 10, 2016
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Thank you for visiting the HIV/HCV Drug Therapy Guide housed on the Toronto General Hospital Immunodeficiency Clinic Web site. General aggregate user data that will be tracked for both the web-based and mobile applications includes country of origin, new vs. returning visitor to the site, browsers used and sections of the guide that are used most frequently. Any identifying personal information will not be collected.
Accessing information from the HIV/HCV Drug Therapy Guide: This web-based application is housed on the Toronto General Hospital Immunodeficiency Clinic Web site at app.hivclinic.ca. Future updates will include an application for mobile devices also.
The Toronto General Hospital website has been in operation since 2000, initially as www.tthhivclinic.com, and since 2009 as www.hivclinic.ca. A second site on HCV information was developed in 2012 at http://www.hcvdruginfo.ca. The main objectives of the drug information portion of the website/app are to provide a comprehensive and centralized repository of current data on HIV/HCV drug therapy for health care professionals with a main focus on drug interactions, and to promote safe and rational prescribing of antiretrovirals and directly acting antivirals. The website/app content is updated regularly, and includes information from key international HIV/HCV conferences and recent publications in the medical/pharmacy literature.
The primary editors of the website/app content are Alice Tseng, Pharm.D., AAHIVP, Editor in Chief, Michelle Foisy, Pharm.D., AAHIVP, Associate Editor, and Pierre Giguère, M.Sc.Phm., AAHIVP, Associate Editor. The ongoing contributions of the following people are also gratefully acknowledged: Christine Hughes, Alison Wong, Bill Cornish, Margaret Ackman, Tony Antoniou, Cara Hills-Nieminen, Deborah Yoong, Natalie Dayneka, Dominic Martel, Denise Kreutzwiser, Cherry Hui, Sanjeev Sockalingham.
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HIV/HCV Drug Therapy Guide. UHN- Toronto General Hospital, Immunodeficiency Clinic; 2016 [insert date cited e.g. cited 2016 Jan 10]. Available from: http://app.hivclinic.ca/
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